Kyle Terada-USA TODAY Sports

49ers left tackle Joe Staley has missed both practices this week

The 49ers might be without their best offensive lineman Sunday.

SANTA CLARA, Calif. - San Francisco 49ers left tackle Joe Staley missed practice for the second straight day Thursday while dealing with a knee injury, leaving his status for Sunday's game on the road against the Giants in doubt.

If Staley can't play, it's likely Alex Boone slides from left guard to left tackle, with either Ian Silberman or Brandon Thomas moving into the starting lineup at left guard.

The 49ers offensive line has struggled so far this season, allowing pressure to Colin Kaepernick on more than 43 percent of his drop backs, according to Pro Football Focus, ranking second-worst in the NFL headed into Week 5. Kaepernick has taken 14 sacks through four games while his offense is the lowest scoring outfit in the league.

The Giants are coming off two straight wins, including an impressive road victory over the Buffalo Bills last week. San Francisco's offense facing the tough task of facing the league's top rushing defense, which hasn't allowed more than 88 yards rushing in a game this season.

Tight end Vernon Davis (knee) and receiver Quinton Patton (concussion) returned to practice Thursday. Davis missed last week's loss after suffering his knee injury in Week 3's loss to the Arizona Cardinals. Patton remains in the league-mandated concussion protocol and has not yet been cleared to play in Sunday's game.

Injury report (Thursday)

49ers

Did not participate: LB Ahmad Brooks (not injury related, shoulder), T Joe Staley (knee)

Limited participation in practice: G Alex Boone (shoulder, ankle), TE Vernon Davis (knee), S L.J. McCray (knee), TE Vance McDonald (chest), WR Quinton Patton (concussion)

Giants

Did not participate: DE Robert Ayers (hamstring), LB Jonathan Casillas (calf), WR Victor Cruz (calf), CB Jayron Hosley (concussion), LB Devon Kennard (hamstring), DE George Selvie (calf)

Limited participation in practice: CB Trumaine McBride (groin)

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Chris Biderman is the Editor-in-Chief of Niners Digest and covers the 49ers from their headquarters in Santa Clara. Chris has been writing about the team since the spring of 2013. The Ohio State alum received his Journalism degree in 2011 and has been working in sports media since 2008. Chris, a Santa Rosa, Calif. native, is also a contributor to the Associated Press covering sports throughout the Bay Area. You can follow Chris on Twitter here.

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