Kelley L Cox-USA TODAY Sports

49ers receiver Anquan Boldin will miss his first game since joining the team

The 49ers receiver will break his 46-game streak Sunday, missing the divisional tilt against the Rams.

49ers wide receiver Anquan Boldin will miss his first game since joining the team in 2013. He's been made inactive against the St. Louis Rams while dealing with a hamstring injury initially suffered two weeks ago against his former team, the Baltimore Ravens.

Boldin's absence means 2-5 San Francisco will play receiver Jerome Simpson for the first time coming off his six-game suspension to open the season. The 49ers were granted a roster exemption for Simpson last week, allowing him to practice with the team despite not being on the 53-man roster.

Following last week's 20-3 loss to Seattle, Simpson was added to the active roster after the team placed safety Antoine Bethea on season-ending injured reserve following surgery on his chest.

Simpson hasn't played since 2013 after getting released during the 2014 season by the Vikings after the team learned of an arrest over the previous summer. His suspension was his third since coming into the league in 2008.

Simpson has 145 catches for 2,004 yards and eight touchdowns in his six-year career. The 49ers' available receivers Sunday will be Simpson, Torrey Smith, Bruce Ellington, and Quinton Patton. Undrafted rookie DeAndrew White was made inactive.

Friday, the 49ers announced starting running back Carlos Hyde would not play while dealing with an apparent stress fracture in his foot. Saturday, the team elevated running back Kendall Gaskins from the practice squad, waiving Jarryd Hayne. Reggie Bush and rookie Mike Davis are the team's other available running backs.

For San Francisco's last ranked offense in both yardage and scoring, Gaskins represents an upgrade over Hayne in pass protection. The 49ers are likely hoping Hayne makes it through waivers and gets back to the practice squad on Tuesday.

49ers inactives:

RB DeAndrew White

RB Carlos Hyde

OL Brandon Thomas

OL Ian Silberman

NT Mike Purcell

WR Anquan Boldin

TE Blake Bell

Rams inactives:

QB Sean Mannion

S Christian Bryant

RB Trey Watts

TE Justice Cunningham

G Cody Wichmann

DE Chris Long

DT Doug Worthington

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Chris Biderman is the Editor-in-Chief of Niners Digest and covers the 49ers from their headquarters in Santa Clara. Chris has been writing about the team since the spring of 2013. The Ohio State alum received his Journalism degree in 2011 and has been working in sports media since 2008. Chris, a Santa Rosa, Calif. native, is also a contributor to the Associated Press covering sports throughout the Bay Area. You can follow Chris on Twitter here.

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