Hyde continues to deal with his foot injury, while Boldin was officially listed as 'doubtful' on Friday's status report.
Boldin missed last week's 27-6 loss to the Rams, ending his consecutive games played streak that dated back to the end of the 2012 regular season with the Baltimore Ravens.
The 2-6 49ers will have their bye week following Sunday's game, which means Hyde will have at least a full month between games if he were to play Nov. 22 game in Seattle.
Additionally, San Francisco's rookie running back Mike Davis has been ruled out for Sunday after undergoing a procedure on his injured right hand, which he injured in last week's loss.
The 49ers are slated to have a new-look backfield after bringing in journeyman Shaun Draughn, who was released by the Browns in October, and former Saints' running back Pierre Thomas, who was released by New Orleans in March.
Joining former practice squad player Kendall Gaskins, the 49ers will spent the week trying to figure out how to divy up playing time within the makeshift group.
"The way they’ve come in and (running backs coach) Tom Rathman, they’re in there with Tom and it’s into the night and they are here and they’re rolling," head coach Jim Tomsula said Friday. "They were out there yesterday. I don’t think we had any (missed assignments) out of those guys. So, they’ve got the skill, they are both good backs. So, the stuff that they are doing and the way they are conducting themselves is really good, really impressive.”
OUT: RB Mike Davis (hand), RB Carlos Hyde (foot), S L.J. McCray (knee)
DOUBTFUL: WR Anquan Boldin (hamstring)
QUESTIONABLE: CB Kenneth Acker (chest, concussion), CB Tramaine Brock (shin), TE Garrett Celek (concussion), CB Keith Reaser (not injury related, ankle)
PROBABLE: G Alex Boone (knee), LB Navorro Bowman (shoulder), LB Ahmad Brooks (shoulder), P Bradley Pinion (right calf), S Eric Reid (chest), T Joe Staley (shoulder)
OUT: CB Robert Alford (groin), LB Justin Durant (calf), WR Leonard Hankerson (hamstring), S William Moore (groin)
QUESTIONABLE: DE Vic Beasley (foot)
PROBABLE: DT Jonathan Babineaux (not injury related), DE Tyson Jackson (ribs), C Mike Person (ankle), G James Stone (calf), CB Desmond Trufant (back), WR Nick Williams (hamstring)
Chris Biderman is the Editor-in-Chief of Niners Digest and covers the 49ers from their headquarters in Santa Clara. Chris has been writing about the team since the spring of 2013. The Ohio State alum received his Journalism degree in 2011 and has been working in sports media since 2008. Chris, a Santa Rosa, Calif. native, is also a contributor to the Associated Press covering sports throughout the Bay Area. You can follow Chris on Twitter here.
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