Kelley L Cox-USA TODAY Sports

49ers running back Carlos Hyde has been ruled out of Sunday's game against the Seahawks

The 49ers will be without their starting running back for the third straight game.

SANTA CLARA, Calif. - 49ers starting running back Carlos Hyde has been ruled out and will not make the trip to Seattle to play the Seahawks Sunday.

Hyde was San Francisco's only player that missed the open portion of practice this week because of injury, while he continues to deal with a stress fracture in his left foot suffered Oct. 11 against the New York Giants. Linebacker NaVorro Bowman was given the day off, as is customary on Wednesdays.

Hyde played on the injury in the following two games, but shut it down prior to the game Nov. 1 against the Rams, and hasn't played in the three weeks since.

With last week's bye, Hyde had four weeks off to help heal the foot before Sunday's trip up to play the Seahawks.

"(The) medical staff just decided that he was a little sore and they just didn’t want to do it," head coach Jim Tomsula said Friday.

San Francisco has dealt with a slew of injuries at the position, including to Hyde's backup Reggie Bush, who was placed on injured reserve after the loss to the Rams following knee surgery to repair a torn meniscus. Rookie Mike Davis suffered a fractured hand in that same game that also required surgery, and he was placed on injured reserve with the return designation.

In the locker room Wednesday, Davis said the procedure on his hand was the first surgery he's ever had.

The 49ers will likely start Shaun Draughn, who impressed in his debut with the 49ers in the 17-16 win over the Falcons.

Draughn ran for 58 yards on 16 carries, and added 38 yards on four catches, after being picked up off the street following all the injuries. The 49ers are Draughn's seventh team since coming into the league as an undrafted free agent in 2011.

The last time the 49ers went on the road to play Seattle, they lost a number of players to injury, including Hyde, who left the game with an ankle injury. Then-starting running back Frank Gore was forced out of the game because of a concussion. Additionally, former inside linebacker Chris Borland had to depart with an ankle ailment that led to getting placed on injured reserve.

The 49ers healthy options at running are Draughn, Kendall Gaskins and Travaris Cadet who was signed last week. To make room on the roster, the team released Pierre Thomas, who notched 12 yards on four carries in his only game with San Francisco against the Falcons.

Receiver Anquan Boldin practiced this week with his hamstring injury and is listed as questionable after missing the last two games while listed with a hamstring injury.

49ers injury report:

Out: Carlos Hyde (foot)

Questionable: Anquan Boldin (hamstring)

Probable: CB Kenneth Acker (concussion/chest), LB NaVorro Bowman (shoulder), CB Tramaine Brock (shin), LB Ahmad Brooks (shoulder), QB Colin Kaepernick (left shoulder), CB Keith Reaser (ankle), S Eric Reid (chest)

Seahawks injury report:

Out: Bruce Irvin (knee), Paul Richardson (hamstring)

Questionable: Marshawn Lynch (abdomen)

Probable: Russell Okung (toe/ankle), Luke Willson (toe), Cliff Avril (ankle), Doug Baldwin (toe), KJ Wright (knee), Demarcus Dobbs (shoulder), Cary Williams (hip), Michael Bennett (toe)

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