The game's hottest QB threw for five touchdowns last week against the Texans, the third time he's done so this season. The Colts have the league's highest-scoring offense and No. 3 overall offense. Manning leads the league in nearly every major passing category.
Adewale Ogunleye/Alex Brown, Bears defensive ends
The Bears' best pass rushers have clicked at the right time this season. After an impressive showing against the Titans, the dangerous duo needs to keep consistent heat on Manning, who hasn't felt much pressure in the pocket this season with 31 TDs.
Another key matchup
Thomas Jones, Bears running back
Whether it's Jones, who's been out two games with a bad toe, or Anthony Thomas, the Bears need a steady running game to keep the Colts' high-powered offense off the field. Rookie Craig Krenzel is still struggling, so Chicago must establish a ground game.
Cato June, Colts linebacker
June is the top tackler for this suspect defense, which is ranked 31st in the league. Offensively, the Bears are ranked dead last -- 32nd in offense. It could be an interesting matchup of bad vs. worse.
COLTS: OUT: LB Gilbert Gardner (hamstring); G Tupe Peko (ankle). DOUBTFUL: WR Troy Walters (upper arm fracture). QUESTIONABLE: G Rick DeMulling (chest); S Mike Doss (groin); T Makoa Freitas (back); CB Nick Harper (shoulder). PROBABLE: LB Gary Brackett (shoulder, thigh); DB Von Hutchins (ill); CB Joseph Jefferson (knee); DE Robert Mathis (groin); S Bob Sanders (rib).
Chicago's first home game of November is marked by Indianapolis' first trip to Soldier Field in four seasons. The Bears have not lost to the Colts since the team moved to Indianapolis from Baltimore prior to the 1984 season, winning al four meetings dating back to 1985. The Colts have not defeated Chicago since a 22-19 overtime decision in 1983 in Baltimore. Indy leads the overall series 21-17, winning 11 of the first 16 matchups from 1953-1960.