Over 1,500 runners competed in last year's event.
Payton, who died Nov. 1, 1999 of liver disease, attended the first Sweetness Fun Run in 1998. This year's host will be former Bears running back Thomas Sanders, a teammate of Payton's from 1985-87.
Two other members of the 1985 Super Bowl championship team, wide receiver Dennis McKinnon and running back Dennis Gentry, are also expected to attend the June 9 event.
Call (630) 859-8606 for more information.