|S Kevin Payne||Back||OUT|
|LB Pisa Tinoisamoa||Knee||OUT|
|RB Garrett Wolfe||Kidney||OUT|
|S Al Afalava||Shoulder||Questionable|
|TE Desmond Clark||Neck||Probable|
|DT Tommie Harris||Knee||Probable|
|CB Charles Tillman||Shoulder||Probable|
San Francisco 49ers
|CB Nate Clements||Shoulder||OUT|
|RB Glen Coffee||Concussion||OUT|
|DT Demetric Evans||Shoulder||OUT|
|OT Joe Staley||Knee||OUT|
|WR Isaac Bruce||Ankle||Questionable|
|G David Baas||Shoulder||Probable|
|CB Tarell Brown||Rib||Probable|
|TE Vernon Davis||Shoulder||Probable|
|RB Frank Gore||Eye||Probable|
|WR Jason Hill||Ankle||Probable|
|WR Brandon Jones||Knee||Probable|
|S Michael Lewis||Quadriceps||Probable|
|RB Michael Robinson||Shoulder||Probable|
|LB Takeo Spikes||Shoulder||Probable|
|S Curtis Taylor||Shin||Probable|
|TE Dalanie Walker||Shin/Knee||Probable|
Bears Offense vs. 49ers Defense
Cornerback Nate Clements (shoulder) isn't expected to be ready for this week. Tarell Brown will likely get the start in Clements' absence. Strong safety Michael Lewis (quadriceps) isn't expected to miss any time. Veteran linebacker Takeo Spikes is recovering from a shoulder injury. He had a quiet game against the Titans last week.
The Niners have the fourth-best run defense (93.2 yards per game allowed) in the NFL. They're keeping the yards-per-carry average of their opponents down, as well (3.4). They've struggled to prevent teams from passing on them, and the loss of Clements isn't going to help their situation. Look for the Bears to continue doing the one thing they've done well: throw.
49ers Offense vs. Bears Defense
The Bears secondary is beat up. Strong safety Al Afalava and cornerback Charles Tillman suffered shoulder injuries last week. Tillman is not expected to miss any time. Afalava may be out, and his backup, Kevin Payne (back), is also hurt. Craig Steltz and Josh Bullocks will need to step up if called upon. The Bears are already playing two backups at linebacker in Hunter Hillenmeyer and Nick Roach with Brian Urlacher and Pisa Tinoisamoa out for the season.
After having looked at the tape of what happened against the Bengals and Cardinals, and considering the state of their line, it would be shocking to not see Frank Gore get 20 or more carries. Expect the Niners to use play action to work tight end Vernon Davis against the Bears' backup linebackers. Rookie receiver Michael Crabtree is becoming more of a factor in their offense. If the Bears can get out to a rare early lead, they can force the Niners to throw. This would allow ends Alex Brown and Adewale Ogunleye to get after quarterback Alex Smith. But the only way to get out to a lead is if this defense can stop someone.
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