NFL Network's Rand Getlin was the first to report the news. McCoy has been dealing with a nagging hamstring injury and Rex Ryan noted yesterday that the running back was playing on 'one-and-a-half legs.'
Through three weeks, McCoy has rushed for 146 yards on 43 carries, good for a 3.4 YPC average. In Week 3, McCoy rushed for 16 yards on 11 carries (1.5 YPC). In his place, it's expected that Karlos Williams will get the start. The rookie running back out of Florida State has been a pleasant surprise for the Bills this season.
Williams has rushed the ball 24 times for 186 yards (7.8 YPC average) and three touchdowns in three games. While Buffalo also has Anthony 'Boobie' Dixon, Williams will most likely receive the bulk of the carries if McCoy is unable to go. Based upon how well he has played this season, many Bills fans will be excited to see what he can do with 15-20 carries in a game.