Miller, Buffalo's starting right guard, is dealing with a groin injury. The Bills lack depth along their offensive line, so it is worrisome to see one of their starters already banged up. Among Buffalo's offensive linemen, Miller is the player who has struggled the most for the Bills. Miller only played 17 snaps last week against the Dolphins, but entering the game, Miller's struggles were apparent. The rookie allowed eight quarterback hurries, one quarterback hit and one sack in 131 snaps. Among offensive guards who have played at least 25 percent of their respective team's snaps, Miller ranks 74th out of 75 eligible guards at Pro Football Focus. Kraig Urbik played well in relief of Miller last week but it's unknown how well he'll fare against the Giants if Miller is unable to play.
As for McCoy and Watkins, Rex Ryan didn't paint the most optimistic picture on Wednesday. He stated that 'it doesn't look good' for McCoy and Ryan told WFAN 660 that Watkins is 'likely out.'
McCoy has been playing on 'one-and-a-half' legs this season due to a hamstring injury that has hampered the running back. His struggles running the ball were apparent on Sunday against the Dolphins as he rushed for 16 yards on 11 carries. Shutting down McCoy for one week may be exactly what the back needs. Karlos Williams has been the team's best back through the first three weeks of the season, so the Bills should be okay short term at the position. While fans want to see McCoy healthy and on the field, there is excitement about seeing Williams get a chance to carry the load against the Giants.
As for Watkins, Buffalo doesn't have a reserve who can truly fill in and be as impactful as the second year receiver. Watkins hasn't had a breakout game in 2015, but opposing teams have certainly game planned for the receiver. That won't be the case for his replacement, Chris Hogan, who will probably see an increase in snaps. Luckily, the Bills still have players such as Percy Harvin, Robert Woods and Charles Clay who will probably benefit the most in regards to targets.
Being without three offensive starters will be a challenge for the Bills, but Buffalo has plenty of talent and depth who can fill in for the time being.