Without Dan Herron, Leodis McKelvin may handle kickoff returns. Back in 2009, a costly McKelvin fumble cost the Bills a victory over the Patriots on Monday Night Football in 2009. McKelvin could find redemption tonight against New England.
Josh Johnson is back to being Buffalo's third string quarterback. Rex Ryan announced that this would be the case for the rest of the season.
New England is missing one of Tom Brady's favorite targets in Edelman and a speed option in Keshawn Martin. This should allow the Bills to double team Rob Gronkowski throughout the evening. Offensive guard Tre Jackson is also out for the Patriots. Defensively, star linebacker Jamie Collins will be out for New England. This is huge for the Bills as Collins was athletic enough to spy Tyrod Taylor and cover LeSean McCoy in coverage. It'll be interesting to see how the Patriots make up for Collins' loss.