“It doesn’t look great right now, but I don’t want to count him out just yet,” said Ryan. “You’ll give him an opportunity."
Williams injured his shoulder on Sunday against the Kansas City Chiefs and was seen in a sling on Thursday according to Joe Buscaglia of WKBW-TV.
The rookie running back has 376 yards rushing and five touchdowns on 66 carries this season.
If Williams cannot play on Sunday, the team has two likely options: Bryce Brown and Mike Gillislee. Brown is currently a free agent after spending training camp and part of the preseason with the Bills. He was recently waived by the Seattle Seahawks, Gillislee is currently a member of Buffalo's practice squad. It's possible that the Bills explore other avenues besides Brown and Gillislee but you'd have to believe that they're among the favorites to play on Sunday for Buffalo is Williams is unable to play.