From 2010-2013, Renfrow played college ball in the ACC. He spent his first three seasons with Virginia and the 2013 season with the Miami Hurricanes. Renfrow played on the defensive line in college according to College Football Reference, but has been playing offensive tackle in the NFL. His offseason/practice squad stints include stays with the Arizona Cardinals, Green Bay Packers, Seattle Seahawks, San Francisco 49ers, and Dallas Cowboys.
To make room for Renfrow, the Bills released safety Phillip Thomas.