The Buffalo Bills have targeted Reggie Bush as a possible replacement for Karlos Williams per reports. That doesn't mean that the veteran running back will sign with the Bills, but if he does 50 percent of the top ten draft picks from the 2006 NFL draft will have played with Buffalo.
As pointed out by Del Reid, the Bills have already had Mario Williams, Vince Young, Donte Whitner, and Matt Leinart on their roster at some point. Among the four players, Williams had the most success in a Bills uniform. Whitner had some success with Buffalo, but his career really took off when he joined the 49ers. Young and Leinart, the first two quarterbacks taken in the draft, had no success during their time with the Bills. Bush wouldn't have to do much to at least be the third most successful Top 10 pick in a Bills uniform if he were to sign.
As for the entire 2006 first round, two other players have donned Bills jerseys and one of them is still on the roster.
Manny Lawson is currently on the roster and is expected to start for the team while Shaq Lawson recovers from a shoulder injury. The McCargo pick never panned out for the Bills.
If Bush signs with Buffalo, almost 22 percent of the first round will have played in Buffalo.