San Francisco 49ers at Cardinals, 4:15 p.m. (EST)
Tim Hightower earned his first career touchdown in week one against SF last year .
Week Two, Sunday, Sept. 20, 2009
Cardinals at Jacksonville Jaguars, 1 p.m. (EST)
Note: The Jaguars finished last in the AFC South in 2008, thanks to a losing 5-11 record.
Week Three, Sunday, Sept. 27
Indianapolis Colts at Cardinals, 8:20 p.m. (EST)
Note: The Cardinals make their Sunday Night Football debut. Al Michaels and John Madden will be on hand at University of Phoenix Stadium. The Colts concluded 2008 with a 12-4 record.
Week Four- BYE
Week Five, Sunday, Oct. 11, 2009
Houston Texans at Cardinals, 4:15 p.m. (EST)
Note: The Texans ended last season at .500, 8-8.
Week Six, Sunday, Oct. 18, 2009
Cardinals at Seattle Seahawks, 4:05 p.m. (EST)
Note:The Seahawks will be an all-around healthier team. Last season, the Cardinals defeated Seattle in both matchups and easily ran away with the NFC West.
Week Seven, Sunday, Oct. 25, 2009
Cardinals at New York Giants, 8:20 p.m. (EST)
Note: This game will mark the Cardinals' second game on Sunday night. They are one of nine teams with multiple appearances on Sunday night. The Giants enjoyed a 12-4 season last year.
Week Eight, Sunday, Nov. 1, 2009
Larry Fitzgerald is ready to win over Carolina again.
Note: This is a matchup to watch. The Cardinals fell to Carolina in week eight but pounced the Panthers in the divisional playoffs. Carolina held an impressive 12-4 regular season record.
Week Nine, Sunday, Nov. 8, 2009
Cardinals at Chicago Bears, 1 p.m. (EST)
Note: Arizona caps the first half of the season with a road game at Chicago. The Bears had a 9-7 season last year.
Week Ten, Sunday, Nov. 15, 2009
Seattle Seahawks at Cardinals, 4:15 p.m. (EST)
Will Seattle be better this year?
Week Eleven, Sunday, Nov. 22, 2009
Cardinals at St. Louis Rams, 4:05 p.m. (EST)
Note: The Rams made key additions through the 2008 NFL Draft but weren't able to make anything happen and finished last in the NFC West with just two wins.
Week Twelve, Sunday, Nov. 29, 2009
Cardinals at Tennessee Titans, 1 p.m. (EST)
Note: This game marks the Cardinals first-ever trip to Tennesee. The Titans were last year's team to beat, 13-3.
Week Thirteen, Sunday, Dec. 6, 2009
Minnesota Vikings at Cardinals, 4:15 p.m. (EST)
Note: The Vikings came to Arizona last year too and spanked the home team, 35-14. Adrian Peterson helped the Vikings to a 10-6 season in 2008.
Cardinals at San Francisco 49ers, 8:30 p.m. (EST)
Note: The Cardinals begin their first of a two-game road trip with the 49ers who finished second in the NFC West last year at 7-9..
Week Fifteen, Sunday, Dec. 20
Cardinals at Detroit Lions, 1 p.m. (EST)
Note: The Lions didn't win a single game in 2008. The big question is who they'll take with the No. 1 overall pick.
Week Sixteen, Sunday, Dec. 27
St. Louis Rams at Cardinals, 4:05 p.m. (EST)
Note: Cardinals fans will get two last chances to see the Cardinals in the regular season. The Rams start a two-game home stretch.
Week Seventeen, Sunday, Jan. 3
Green Bay Packers at Cardinals, 4:15 p.m. (EST)
Note: Green Bay, who the Cardinals also play in the preseason, will be make its first regular season visit to Arizona since 2003. Green Bay finished 6-10 without Brett Favre.