After hitting Antonio Gates, Drew Brees connected with Reche Caldwell for 22 yards. On third down, Brees again went to Caldwell who got the first down but fumbled the ball on the Eagles' 19-yard line and Philadelphia recovered. The play was reviewed and the ruling on the field was upheld, ending the Chargers chances for even a tie.
The Chargers got on the board in the third quarter with a 13-play, 74-yard drive that took over six minutes off the clock. Brees hit Keenan McCardell over the middle for a 19-yard touchdown. Brees went 7–for-9 for 75 yards on the drive.
After a 22-yard punt from Dirk Johnson, which gave the Chargers the ball at the Eagles 43, Brees connected on five of six passes, including his third to tight end Gates on the drive that resulted in a touchdown and gave the Chargers a 14-10 lead.
Jamar Fletcher, playing in relief of Sammy Davis, picked off the next pass from Donovan McNabb at the Eagles' 33. He returned it to the 14-yard line. A holding call and a sack on Brees meant Nate Kaeding. Kaeding connected from 33 yards out to give San Diego a seven point lead.
With seven minutes to go in the game, Mark Simeneau hit the hand of Brees as he threw the ball, causing the ball to pop in the air and be corralled by Jeremiah Trottier at the San Diego 23. Todd France brought the Eagles within four at 17-13 with a 40-yard field goal that hit the left upright and caromed through.
Terrence Kiel forced a fumble, which was recovered by Steve Foley midway through the second quarter, but a roughing the passer call on Randall Godfrey for picking up McNabb and slamming him to the turf negated the play. It was the second personal foul called on San Diego during the drive and the Chargers would commit three penalties on the drive. McNabb eventually hit Terrell Owens for a touchdown from four yards out to put the Eagles in the lead, 7-0.
McNabb completed 14 straight passes during the first half with his first incompletion coming as a spike with 42 seconds until half. The Eagles had a chance to score just before halftime but had no timeouts and could not set the line to spike the ball before the clock ran out.
The Eagles drove the length of the field on their opening drive of the second half. McNabb connected on six straight passes to get inside the ten-yard line before missing three straight attempts. The Eagles settled for a 24-yard field goal from Todd France to extend the lead to 10-0.
The Eagles held LaDainian Tomlinson to seven yards rushing on 17 carries. Tomlinson also failed to score, ending his streak of 18 consecutive games with a touchdown, leaving him in a tie with Lenny Moore on the all-time list.