The ensuing kickoff was returned 42 yards by Terrence McGee to the San Diego 47-yard line. After their drive stalled, Ryan Lindell connected from 53 yards out.
The Chargers got lucky on their second drive when Eric Parker fumbled but the call on the field was down by contact – a play that is not challengeable. Two plays later, Brees hit Antonio Gates for a 27-yard touchdown to give the Bolts a 14-3 lead. The Chargers extended the lead to 18 points when Brees hit Eric Parker for a 23-yard touchdown. Parker beat Nate Clements on a double-move as the Bills' cornerback bit on the pump-fake from Brees.
On the first play from scrimmage following the Chargers third touchdown, Willis McGahee fumbled and Randall Godfrey recovered the ball at the Bills 22. And for the second time in the game, the Chargers went for it on fourth and one inside the Buffalo ten. Brees hit Neal in the flat for a touchdown as the Bolts went up 28-0.
The Chargers answered quickly in execution of the two-minute drill. Brees hit Keenan McCardell on a 26-yard pass that pushed McCardell past Lance Alworth for 21st on the all-time receiving yards list and McCardell would catch the touchdown score from 29 yards out for a 35-10 Chargers lead.
The Chargers tacked on three more with a Nate Kaeding field in the third quarter and got another three with Kaeding's second field goal of the game early in the fourth quarter.
The lead was padded on the back of Michael Turner who used some hard running to get in the end zone. Turner had seven carries for 44 yards on the drive.