Manning, however, says that all the talk of Indianapolis possibly joining the likes of the 1934 Chicago Bears and the 1972 Miami Dolphins as the only teams in league history to finish a regular season undefeated is a tad premature.
In fact, he would much rather talk about this week's home game with a San Diego Chargers team that desperately needs a victory to stay in the playoff chase.
The Chargers will bring an 8-5 record into Sunday's game and face must-win scenarios over the final three weeks. Manning knows that after last year's 34-31 overtime comeback win over San Diego, Sunday's matchup won't be an easy one.
"I think it's disrespectful if you're talking about two games from now instead of talking about the team you're playing next," he said this week. "These teams are too good to not give them the respect that they deserve."
And the Chargers have Indianapolis' respect.
"They have excellent players, first and foremost," Manning said. "I know what kind of challenge our defense has in facing their offensive players. Their defense is outstanding, too. They've a very active team on both sides of the ball, and it's going to be a tough test for us.
"I think that we've improved every week. That's the goal this week, to try and improve as a football team, and hopefully that can result in us beating San Diego. It will be a tough challenge. Their record is not indicative of how good a team they are."
In other words, business as usual for the Colts this week. With the exception of injured players, everybody will play against San Diego.
"This is just like every other week, a businesslike approach. We have a tough AFC game at home. I think that's been the theme of this team all year. To truly take it one week at a time," Manning said. "That's why we have been able to take care of business up to this point. We've treated every opponent with the same respect."