Tomlinson surpassed the 10,000-yard mark with his five-yard carry that pushed the game to the two-minute warning in the first half. He is the first player to hit that mark at this stage of a career, two games into his sixth year in the league.
Tomlinson amassed 122 yards on the day, 71 on the ground and 51 yards on seven receptions.
Michael Turner set a career-high with 138 yards rushing, accomplishing the feat on just 13 carries for a 10.6 average. His previous high was the 113 yards he pounded out against Indianapolis on December 18, 2005.
Turner's 73-yard run in the fourth quarter was the second longest of his career, ten yards shy of the 83-yard touchdown he recorded in Indianapolis last season.
"I love to see Mike run," said Tomlinson. "He is such a powerful guy and it is hard to tackle him. A guy who knows exactly what he is about. He runs people over."
McCardell also came into the Titans game with 10,698 career yards, ranked 19th on the NFL's all-time list, behind former New England Patriot Stanley Morgan, who finished his career with 10,716 yards. The aforementioned 13-yard reception tied him with Morgan before a 15-yard catch on the same drive pushed McCardell into 18th place. Gary Clark's 10,856 yards stand next on the list.
He ended the day with five receptions for 58 yards. The only active player with more catches than McCardell is Indianapolis' Marvin Harrison with 936. Irving Fryar is next on the all-time list with 851.
"His ability to manage the game is probably one of his greatest strengths because of his leadership and the charisma that he brings to the team," Tennessee offensive coordinator Norm Chow said.
Philip Rivers set career-highs in completions (25), attempts (35) and yards (235) on Sunday.
"He had a couple of throws he barely missed," head coach Marty Schottenheimer explained. He was very efficient again. We didn't turn the ball over again. That is always paramount."
With the Chargers up 33-7, Charlie Whitehurst received his first snaps in a regular season game. His first handoff was perfect – it was the start of a 73-yard run by Michael Turner. Whitehurst would get the first touchdown of his professional career, taking a quarterback keeper 14 yards for the score.
Quentin Jammer picked off a pass on fourth-and-7 with time running out in the third quarter, matching his total from last season. It was his first pick since December 18, 2005.
"Philip just threw it out there," Jackson explained. "He knew I'd accelerate and go get the ball."