Buffalo closed to within three points with thirty seconds to go, getting a three-yard touchdown reception from Peerless Price to make the score 24-21.
The onsides kick was touched by a Bills player before it reached ten yards, giving San Diego the ball and the game.
The Chargers turned a Quentin Jammer first quarter interception into three points with a 42-yard field goal from Nate Kaeding. It snapped team record streak of 19 straight scoring drives that ended in a touchdown.
LaDainian Tomlinson got on the board with a 51-yard touchdown run, following a Lorenzo Neal block down the left sidelines to put San Diego up 10-0.
The Chargers tacked on seven more points just before the half – Philip Rivers hitting Antonio Gates for an 11-yard touchdown to put the Bolts ahead by 17 points. The drive was setup when Rivers hit Gates on a seam route for 26 yards.
The momentum shifted quickly in the third quarter.
Buffalo took advantage of a third quarter Rivers fumble deep in San Diego territory to trim the margin to ten points. J.P. Losman hit tight end Robert Royal from five yards out for the touchdown, capping the 19-yard drive.
Jim Leonhard's 34-yard punt return two minutes later had Buffalo inside the San Diego 15. Willis McGahee's one-yard run cut San Diego's lead to 17-14 with eight minutes still left on the clock in the third quarter.