But Holmes will return to Invesco Field this week looking nearly as strong as ever.
He no longer leads the league in rushing as he did in 2001, or in yards from scrimmage (though he trails only Deuce McAllister) as he did over the past two seasons.
But coming off his 35-touch, 186-yard, two-touchdown effort in Kansas City's 28-24 win at San Diego, Holmes looks ready to lead the Chiefs into December and beyond.
In rushing for a season-high 162 yards on 31 carries, Holmes had his first century running game in his last five outings. He added four more touches on receptions to post the busiest workday yet in his 2 3/4 seasons in Kansas City.
Not bad for a guy too many people tried to write off shortly after he left Invesco Field on crutches last Dec. 14 with a hip injury that immediately brought to mind memories of Bo Jackson.
But there was no stopping Holmes early as he rushed for 112 yards in the first half against the Chargers. He had 34 of the 56 yards in KC's first scoring drive, which he capped with his first TD. He had half of the 70 yards for his second TD that put KC up 14-0 early in the second quarter.
Holmes carried five straight times, his fifth run being a juking 13-yarder to the goal line, the plane of which he appeared to break without getting the TD call. He was less fortunate on runs 6 and 7, which the Chargers stuffed for loss.
"It's a matter of playing good football in December when you get the opportunity," Holmes said of his best all-purpose game of the season. "You know what they say -- it's the things you do in December that you're remembered by. That's what I'm hoping to do."