The classic strategy for the Cover 2 of tackling the running back on the way to the quarterback will need to hold true in this game, due to the fact that the Patriots will likely come out on the attack, throwing early and often -- and probably throwing deep late even if they have a big lead.
With the running game mostly an afterthought, the Colts may want to open up in a defense similar to what Bill Belichick himself used against them in 2003 and 2004, with a soft zone, seven men in the box, and 3 (or fewer) defensive linemen. While a Tony Dungy-coached defense is not going to come out with fewer than four defensive linemen, there is more depth in the secondary for the Colts than there is at linebacker. They may want to consider nickel and dime looks, even on first down, until New England proves that they can be as deadly running the ball as they are throwing it.
The true threat from the running backs will be their receiving skills. Kevin Faulk and Maroney are excellent receivers with soft hands who can be dangerous after the catch. In his first action since Week 3, Maroney caught two passes for 37 yards (18.5 yard average) that were basically flare passes out of the backfield. In spot duty, mostly playing on third down and occasionally subbing in for Maroney, Faulk has 22 receptions already this season.
Bottom line: If Maroney ends up with 100 yards rushing, that is a win for Indianapolis. Unless a large percentage of that comes off a long touchdown run, the more Maroney touches the ball, the better it is for the Colts, because it would mean that the Patriots are not successful throwing the ball.