With the win, the Colts became the first team in the history of the NFL to post 12 or more wins in five consecutive seasons.
The Colts also clinched their fifth-straight AFC South title and locked up the No. 2 seed in the AFC playoffs and a first-round playoff bye. New England clinched the AFC's top seed with a 20-10 win over the New York Jets earlier in the day.
In Oakland, the Colts squandered several chances for touchdowns in the red zone, settling for 19- and 22-yard field goals from Adam Vinatieri and getting stopped on fourth-and-goal from the 1-yard line another time.
Anthony Gonzalez scores the go-ahead touchdown in the fourth quarter
AP Photo/M.J. Sanchez
The Raiders used the stops to catch up after falling behind 10-0 early, and Justin Fargas bulled over from the 2-yard line with 10:29 left in the game to give Oakland a 14-13 lead.
The Colts' offense didn't score a touchdown until just 4:49 remained in the game — a 20-yard pass from Peyton Manning to Anthony Gonzalez. That gave the Colts a 19-14 lead and Joseph Addai scored on a two-point conversion to give Indianapolis its final margin.
Oakland drove down the field late in the game, but a fourth-down pass with 1:50 left fell incomplete, allowing the Colts to breathe easily.
Manning finished the game with 276 yards passing and completed 22-of-39 attempts, with one touchdown and one interception. The running game struggled, gaining just 58 yards on 20 attempts. Joseph Addai had 44 yards on 15 attempts.
T.J. Rushing had a 90-yard punt return for a touchdown for the Colts in the first quarter, staking Indianapolis to a 10-0 lead.
Fargas picked up 89 yards on 26 attempts for Oakland. Former Colt Dominic Rhodes gained 41 yards on seven carries for the Raiders, and QB Josh McCown completed 13-of-24 passes for 94 yards. Rookie quarterback Jamarcus Russell completed 2-of-5 passes for 10 yards.