Colts QB Peyton Manning vs. Chargers pass defense
Manning threw six interceptions the last time these two teams matched up, in November. He was also sacked twice. The Colts have had their problems in the past with defensive teams that use the 3-4. And San Diego has some great linebackers, along with a strong secondary, to cause some problems.
Rivers has had a good season for the most part, although he has shown some inconsistency. He was sacked twice in the last meeting between the two teams and was picked off twice.
Mathis, meanwhile, missed the final four games of the regular season with sprained knees. With the loss of DE Dwight Freeney to a season-ending foot injury, Mathis' ability to rush the passer and cause havoc will be important.
Harrison missed most of the regular season due to an injured left knee. He is expected to return to the starting lineup against the Chargers, although it's not know how much he will play. Wayne had 104 catches for 1,510 yards and 10 touchdowns. Cromartie has a league-leading 10 interceptions. Jammer had one.
The league's best running back against the recently named Associated Press 2007 Defensive Player of the Year. Both play with emotion, in addition to being great athletically. This may be the best one-on-one matchup of the day.