The Colts rallied from a 13-9 halftime deficit and began turning field goals into touchdowns in the second half.
The Colts took their first lead on a 23-yard pass from Peyton Manning to Joseph Addai for a 16-13 advantage, but it didn't last long, as Texans rookie Steve Slaton ripped off a 71-yard touchdown run just three plays later, giving Houston the lead back with 9:30 left in the third quarter.
Clint Session led the Colts' defense with eight tackles
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However, Manning and the Colts' offense were just getting warmed up. Manning quickly led the Colts down the field again, hitting on passes to Anthony Gonzalez, Reggie Wayne and Marvin Harrison before Joseph Addai scored from seven yards out to give Indianapolis the lead back.
It was a remarkably efficient third quarter for the Colts, who held the ball for all but 3:26, picked up 14 first downs (seven running, seven passing) and converted all three of their third-down tries.
That efficiency paid off on the first play of the fourth quarter, as the Colts capped an 11-play, 73-yard drive with a pass from Manning to Harrison, who battled to get into the end zone from 10 yards out for a 30-20 lead.
The Colts would take the clock under two minutes and add another field goal from Adam Vinatieri to establish the final score, and Melvin Bullitt was able to intercept Rosenfels with 44 seconds left to seal the win.
Manning had one of his finest games of the season, completing 30 of 46 passes for 320 yards, his highest yardage total of the season. With two touchdowns and no interceptions — the third straight game without an interception — Manning had a passer rating of 99.9, his fourth-highest rating of the season.
Harrison had nine catches for 77 yards, and Wayne added seven for 90. But perhaps the best statistic was the rushing total for Addai, who had 105 yards on 22 carries, the first 100-yard day for a Colts back this season. Rhodes matched Addai's 4.8 yards-per-carry average with 10 carries for 48 yards, as well.