— Colts coach Tony Dungy has a 2-3 career record against San Diego.
— Indianapolis has a 38-15 road record since Tony Dungy became head coach in 2002. The Colts' .717 road winning percentage is second behind New England's .731 (38-14) in games played since the start of the 2002 season.
— The Colts have posted an NFL-best 108-46 regular-season record since 1999.
— Indianapolis has a 3-0 record so far this season against teams that primarily use a 3-4 defensive scheme: Baltimore, New England and Pittsburgh.
— In his past three games this season (against New England, Pittsburgh and Houston), QB Peyton Manning has completed 72 of 115 passes for 814 yards, seven touchdowns and no interceptions for a 104.0 passer rating. He has completed 62.6 percent of his passes in those games.
— Manning leads the NFL with seven touchdown passes in the month of November.
— Manning has completed 128 of 222 passes (71.3 percent) for 1,588 yards, eight touchdowns and 11 interceptions in five career meetings with the Chargers. He has a 3-2 regular-season record in games played against San Diego.
— Manning is averaging 49.7 passes in his last four regular-season games with the Chargers. He is also averaging 362.5 yards passing in those games.
— Manning has thrown six touchdown passes and 10 interceptions in his last three games against San Diego, including postseason meetings.
— "That's what they have done with us. We've turned the ball over. I know last year (in the playoffs) we had one at the two-yard line, and we turned it over right before the half and didn't get a field goal when we had a chance. We went for it on fourth down inside their 10. We had six turnovers in the game out there (last year). It's just one of those where we have to do what we've done the last three weeks, do our job and take care of the ball. Nothing spectacular, but execute well and see if we can hold their running game down." — Colts coach Tony Dungy, on San Diego forcing Indianapolis into turnovers in recent games.
— "Yes, it was. You never know quite what's going to happen here late in the season, but it's an important game for both teams. Both teams are fighting and hanging in there in the AFC, and that's why I think it'll be a good ballgame." — QB Peyton Manning, on how bizarre last year's regular-season meeting with the Chargers went.
— "(Assessing the progress) is really not for me to do. We're on a one-week-at-a-time type of situation. It was a good win for us this past Sunday, but it's a whole new challenge this Sunday. It's a whole different style of defense, different players, and we need to try to get better this next week than we were this past week. We need to build on some of the things we're doing well, but we need to do a better job in the red zone this Sunday than last Sunday. The field goals were nice, and (K) Adam (Vinatieri) made some great kicks, but we'd like to score more touchdowns when we get down there. Those are things we can build on, and hopefully we will." — Manning, on the progress of the Colts' offense in recent weeks.
BY THE NUMBERS: 6 — The Colts will be shooting for their sixth consecutive win in the month of November.
QUOTE TO NOTE: "They've all been kind of the same script. They've been close games. (San Diego) has been ahead of us for the most part, except the playoff game (last year) we were ahead and couldn't hold the lead. But, it really comes down to making those plays in the fourth quarter when the game's on the line. So, I don't know that we're going to do anything different but hopefully make some of those plays that you have to make. They're a good football team. They have a lot of talented guys. That New England game that was on TV (Oct. 12 in San Diego), that was one of the most impressive games I've seen played this year. That's what they're capable of, so that's what we have to go out expecting to get, that type of game, from them. We're going to have to play well to win, but in terms of style or is there anything we need to do differently? I don't think so. I think it's just, 'Make some of those critical plays.' " — Colts coach Tony Dungy, on his team's recent games with San Diego.
STRATEGY AND PERSONNEL
He has received extended work in the last two games with Pittsburgh and Houston, filling the role of a "big" defensive tackle for the Colts.
"This upcoming game (at San Diego) will probably be more his style of game with a lot more powers and double teams," said Colts coach Tony Dungy.
— WR Reggie Wayne (ankle) practiced Wednesday and is expected to start Sunday against San Diego. Wayne has been bothered by a gimpy ankle for the past three weeks but has not missed a game. He tweaked the ankle again while playing against Houston this past week but remained in the game.
— S Antoine Bethea (ankle) was held out of Wednesday's practice. Bethea is nursing a sore ankle but is expected to play Sunday at San Diego.
— LB Gary Brackett (quadriceps) did not practice Wednesday. Brackett should be able to start Sunday night's game at San Diego.
— DE Dwight Freeney was allowed to sit out the Wednesday practice. He should be able to return for Thursday's workout and start against the Chargers on Sunday night.
— CB Tim Jennings did not practice Wednesday in order to rest old injuries. Jennings is expected to return for Thursday's practice and start Sunday at San Diego.
— DE Robert Mathis (toe) was held out of Wednesday's practice. Mathis saw limited practice time a week ago but was able to start against Houston. The same prognosis is expected for this week's game at San Diego.
— DT Darrell Reid (hip) was held out of the Wednesday practice. Reid is expected to be available for Sunday night's game with San Diego.
— CB Brandon Foster has been signed to the active roster. Foster had been an undrafted free agent with Indianapolis since last spring and has spent time on the team's practice squad.
— QB David Greene has been released from the Colts' practice squad.
— TE Eric Butler, who had been added to the practice squad last week, has been released.— CB A.J. Davis has been re-signed to the practice squad. Davis had been on the Colts' practice squad earlier this month.
— WR Marques Hagans has been added to the practice squad. Hagans, who played collegiately at Virginia, was a fifth-round draft choice of the St. Louis Rams in 2006. He has also spent time with the Kansas City Chiefs.
— S Brannon Condren has been re-signed to the practice squad. Condren had been a fourth-round draft pick by Indianapolis in 2007. He was released at the end of training camp this year and had been signed by the St. Louis Rams. He also saw playing time with the Miami Dolphins this season.
INJURY IMPACT: S Bob Sanders (knee) did not practice Wednesday. He hopes to be available for Sunday's game at San Diego. Sanders did not play against Houston this past week.
— CB Kelvin Hayden (hamstring) has been making good progress during his rehab and might be able to return to practice this week. Hayden did not practice Wednesday. His availability for the San Diego game won't be known until Friday or Saturday.
— WR Roy Hall (hamstring/knee) did not practice Wednesday. His status for the Chargers game remains unclear.
— TE Tom Santi (shoulder) has been placed on the Colts' injured reserve list. Santi will be sidelined for the remainder of the season.
— CB Nick Graham (ankle) has been placed on the team's injured reserve list. Graham will be out for the rest of the year.