KICKOFF: Sunday, 8:15 ET
TV: NBC (Al Michaels, John Madden, Andrea Kremer)
SERIES: 23rd regular-season meeting. The Chargers lead the series, 14-8. Last year the Chargers took a regular-season and playoff game from the Colts. In a Sunday night game in 2007, the Chargers built a 23-0 lead and held on for a 23-21 victory. In the playoff game, backup QB Billy Volek's 1-yard run ousted the Colts from the postseason in the last game at the RCA Dome.
PREDICTION: Chargers 24-21
KEYS TO THE GAME: If the Chargers don't stuff RB Joseph Addai — who is coming off his first 100-yard game of the season — they'll have no chance of getting off the field. San Diego isn't rushing the passer well, which is directly linked to the pass defense sitting at the bottom of the league allowing 267 yards per game. If Manning is getting help from Addai and can throw off play-action, the Chargers' beleaguered secondary can't put up much of a fight. ... The Chargers kick off a three-game homestand, and QB Philip Rivers is 18-2 in 20 career starts at Qualcomm Stadium. But it's the ground game the Chargers want to focus on. San Diego is averaging just 93.1 rushing yards per game, but this is an opportunity for RB LaDainian Tomlinson to provide more balance to the offense. While the Colts' run defense has improved in recent weeks, it is still allowing 135.8 yards per game and could be without SS Bob Sanders.
KEY INJURIES: Colts: CB Kelvin Hayden (hamstring) is expected to start after missing six games; Sanders (knee) hopes to play after sitting out last week. Chargers: DE Luis Castillo (groin) is uncertain.
NEED TO KNOW: Manning has thrown eight touchdowns against 11 interceptions in five career regular-season meetings. He threw six in San Diego last Nov. 11. ... With one touchdown, Tomlinson will tie Marshall Faulk (136) for the fifth-most in NFL history.
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