KICKOFF: Sunday, 1:00 ET
TV: CBS (Dick Enberg, Randy Cross)
SERIES: 25th regular-season meeting. Browns lead, 13-11. The Browns hold the series edge, but they have beaten the Colts only once in seven games since 1992 when they won 21-14 in 1994. The Browns beat the Colts six straight times between 1978 and 1986. Cleveland has never beaten Indianapolis since the Colts drafted Peyton Manning. Manning is 4-0 against them.
PREDICTION: Colts 30-23
KEYS TO THE GAME: The Colts have spent the week talking about how difficult it can be to move the ball against the Browns' 27th-ranked defense. The reality is the Browns have just 15 sacks on the season and their secondary doesn't run deep enough to stick with WRs Reggie Wayne, Marvin Harrison and Anthony Gonzalez and TE Dallas Clark if QB Peyton Manning has time in the pocket. Cleveland's best chance is for NT Shaun Rogers to take advantage of backup rookie C Jamey Richard and at least take RB Joseph Addai out of the game. ... QB Derek Anderson is back under center, but facing the Colts' high-powered offense and with snow flurries possible, the Browns' offense is likely to be more run-based than normal. Look for RB Jamal Lewis to get at least 20 carries, with speedy backup Jerome Harrison also significantly involved in the game plan. Cleveland needs to play keepaway to protect its defense, and the Colts allow 136.8 rushing yards per game.
KEY INJURIES: Colts: LT Tony Ugoh (quadriceps) is uncertain; SS Bob Sanders (knee) is likely out; C Jeff Saturday (calf) is out. Browns: S Sean Jones (ankle) should play; QB Brady Quinn (finger) is out.
FAST FACTS: Colts WR Marvin Harris has averaged 118 receiving yards in three career games at Cleveland. ... Browns WR Braylon Edwards has been charged with 17 dropped passes this season.