The Colts improved to 6-0 for the fourth time in the last five seasons. The NFL's unbeaten list was whittled to three after Sunday's games, with the Saints and Broncos joining Indy atop the standings.
The Colts were in control of this game from the beginning, marching 90 yards on 12 plays on their opening drive. Peyton Manning found Reggie Wayne on a slant route for a six-yard touchdown, new kicker Matt Stover tacked on the extra point, and the Colts were off to a 7-0 lead.
St. Louis was able to answer with a 69-yard drive that ended in a Josh Brown field goal, but the Colts were interested in touchdowns, not field goals. Manning found Clark on a 27-yard beauty for another touchdown, and Joseph Addai strolled in for another score in the second quarter. At halftime, the Colts led, 21-3.
Brown added another field goal in the third quarter, but an interception return for a touchdown by rookie cornerback Jacob Lacey kept the visitors comfortable in front at 28-6.
In the fourth quarter, Manning tossed another touchdown pass, this time to rookie Austin Collie, and Chad Simpson scored his first NFL touchdown on a 31-yard run up the sideline to close out the scoring.
""We certainly feel that we played pretty well," coach Jim Caldwell said. "Obviously, we had some rough spots there in the game a little bit, but the great thing about it that these guys prepare well, they practice hard, the play hard and it shows. I think it showed today. The other great thing is that they will take this and celebrate for a short period and get right back to work. Overall, I think we did most things pretty well. We ran the ball decently, we were able to move the ball when we had the opportunities, we did get stalled a couple of times.
"Defensively, early in the game, specifically the first half, I think we did a good job of stopping the run. You have to give them a lot of credit that big strong back (Steven Jackson) is very difficult to handle. He got loose on us in the second half and I am certain he had some pretty big numbers. He is a guy who can certainly be overpowering and one that can dominate the game as well."
Manning was his usual efficient self, hitting on 23-of-35 passes for 235 yards and the three touchdowns. His passer rating was a stellar 116.7. Wayne caught seven passes for 83 yards, while Collie had four grabs (36 yards), and Clark (44 yards), Gijon Robinson (38 yards) and Pierre Garçon (24 yards) all had three catches.
The Colts also ran the ball well, with Addai 64 yards on 20 carries), Donald Brown (2-58) and Simpson (3-35) combining for 156 yards and six yards per carry.
The Colts' defense, bolstered by the return of Bob Sanders, made it a tough day for the Rams, particularly quarterback Marc Bulger. In addition to Lacey's pick and score, Kelvin Hayden also had an interception. Bulger finished with just 140 yards passing and a 37.3 passer rating.
Jackson did have big numbers, with 23 totes for 134 yards, but he was the lone bright spot on the Rams' offense, which never got inside the Indianapolis 10-yard line.
Antoine Bethea led the team with eight tackles. Daniel Muir had his best game since joining the team in 2008; the defensive tackle recorded an impressive seven tackles, one for a loss, and shared a sack with Clint Session. Dwight Freeney and Eric Foster also had sacks for the Colts.
Indianapolis hosts San Francisco at Lucas Oil Stadium next Sunday to open a three-game homestand.
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