Tony Romo's sore thumb appeared fine and the Dallas Cowboys were driving down the field on the way to taking a 14-0 lead.
Then Terrell Owens sprained his left ankle, the offense stalled and the concern about Owens' overshadowed Dallas' 20-13 victory over the Panthers on Saturday night.
While Dallas (13-2) moved a step closer to clinching home-field advantage throughout the playoffs behind a solid defense and an improved running game, the Cowboys were dealing with another injury to a key offensive player.
Last week it was Romo, who bruised his right thumb and was ineffective in a loss to Philadelphia. Now it's Owens, who left in the second quarter after his left leg got caught underneath him after a catch.
"I think it's just a high ankle sprain," Dallas owner Jerry Jones said. "According to the X-ray, that's all we see. We'll take another look at it tomorrow."
The Cowboys made it 14-0 a play after Owens left, but failed to score another touchdown and were greeted with Owens wearing a boot on his left foot after the game. He didn't speak to reporters.
Romo threw for 257 yards and a touchdown, but wasn't as effective without his top target.
"Obviously he's an explosive player who's going to obviously be missed if he's not back," Romo said. "I haven't heard anything. I don't know if he's coming back next week or what."
After the Panthers (6-9) cut it to 20-13 on John Kasay's 25-yard field goal with 3:01 left, the Panthers decided not to try an onside kick.
The Cowboys then put it away on Marion Barber's 11-yard run for a first down with 1:45 left.
Barber rushed for 110 yards on 22 carries to help Dallas match the 1992 team for the most victories in franchise history.
But despite improving to 7-0 on the road, the Cowboys struggled to put away the Panthers, who started undrafted rookie Matt Moore for a second straight week.
Moore, who like Romo went undrafted and spent training camp with the Cowboys, threw for 182 yards. He threw his first NFL touchdown pass to Steve Smith in the second quarter, and connected with Smith on a 57-yard pass play that led to Kasay's final field goal.
But Moore was intercepted once and sacked five times, twice by DeMarcus Ware and the Cowboys' defense was strong despite the absence of Roy Williams, who was serving a one-game suspension for an illegal "horse-collar" tackle.
"I think there were some good things and there's obviously stuff to work on," Moore said. "That interception in the second half was just a bad read."
Smith caught nine passes for 137 yards, but the Panthers managed only 67 yards rushing and were officially eliminated from playoff contention.
After the game, Carolina coach John Fox refused to discuss an NFL Network report that owner Jerry Richardson said Fox and general manager Marty Hurney would return next year despite their second straight non-winning season.
"I won't address that or any conversations until the season is over," Fox said.
While the Panthers' season will end next week, the Cowboys will clinch home-field throughout the playoffs if Green Bay loses at Chicago on Sunday.
"We still ran all the same plays we run when he's in there," said receiver Patrick Crayton, who starts opposite Owens. "I think once 81 was out, once T.O. was out, they started playing more man. That's fine. That's how we like it. We hate playing against zone. I think zone should be outlawed by the NFL."
Romo, shaking off the distractions from last week's poor play and the publicity over girlfriend Jessica Simpson's appearance, completed 28 of 42 passes and had one interception.
There was no sign of Simpson, although a trio of portly male fans wore blond wigs and a handful of others wore Simpson masks.
Cowboys Beat Carolina, 20-13
CowboysHQ Top Stories
Cowboys David Irving Fails Drug TestPromising Dallas Cowboys Defensive Lineman David Irving Fails Drug Test, Will Appeal, Reports Fish
Cowboys OTAs Preview: Step-Ups + ShowdownsDallas Cowboys OTAs Preview, Today Inside The Star In Frisco: 3 Step-Ups And 3 Showdowns
On Eve Of Cowboys OTAs, Witten's 'All In'Jason Witten talks of a commitment to make his community better, a commitment to making the Dallas Cowboys' present chances of competing for a Super Bowl better, and a commitment…
CowboysHQYesterday at 2:55 AM
Cowboys 1st+10: Dallas and Kaepernick? NoIn this edition of Dallas Cowboys 1st and 10, we wrap up the week with some Colin Kaepernick talk, and why the Cowboys likely aren't interested in him.
CowboysHQSunday at 6:43 AM