But the Dolphins have defended Manning very well through the years, and that's a big reason they've had such success against the Colts.
The Dolphins have beaten the Colts eight times in the 10 meetings with Manning at quarterback, and his numbers during that time aren't that impressive.
Manning is completing over 60 percent of his passes against the Dolphins, but he also has thrown more interceptions (17) than touchdowns (14).
Manning is playing perhaps the best football of his career right now and he certainly has to rank as one of the MVP contenders at this point in the season.
The key for the Dolphins Sunday will be slowing down Marvin Harrison, who just might be the best wide receiver in the game and is clearly Manning's favorite target.
Stopping Manning and Harrison is a challenge the Dolphins are looking forward to.
"If you want to be the best, you have to beat the best," said cornerback Patrick Surtain, who has two career picks against Manning. "He's probably the best receiver in the league right now, statistically. The guy has great moves. He's Peyton's go-to guy. It's going to be a formidable challenge for all of us, not only me but everybody on the defense. The D-line getting pressure on Peyton, making him force his throws or whatever. (I am) just looking forward to this game."