The loss of Boston is particularly damaging because he was being counted on heavily to give the offense some big plays, something made more important by the retirement of Ricky Williams.
Boston sustained a torn patellar tendon on Friday while running a deep pattern in one of the practices with the Houston Texans.
Boston had complained not long before of soreness in his knee, but the Dolphins have said the knee checked out and the time and Boston was asked if he wanted to give it a try.
As for Akins, he was hurt during the Saturday scrimmage.
His loss won't affect the defense, but he was expected to play a significant role on special teams. That is, after all, the reason the Dolphins signed him as a free agent after Akins played last season for the Super Bowl champion Patriots.
Injuries devastated the receiving corps throughout the weekend, with Coach Dave Wannstedt referring to his unit at one point as "slaughtered."
The bad news over the weekend extended to the play of the offense, which failed to get into the end zone in the scrimmage against Houston.
Jay Fiedler got the better of A.J. Feeley in the first round of the quarterback battle as he completed 5 of 6 passes. But all five of Fiedler's completions went to running backs and they were good for only 18 yards.
Feeley, for his part, was 2-for-5 for 30 yards. He wasn't helped by a fumble by reserve tight end John Jones, who is out of shape, missed the team flight to Houston and is quickly working his way off the team.
Among the only bright spots this weekend were the play of defensive end Jason Taylor, who was a factor in the pass rush, and rookie cornerback Will Poole, who continues to make big plays every time he steps onto the field.
But overall, it was a very difficult weekend for a Dolphins team that can't handle many more setbacks before the game start counting on Sept. 12.