Then they clinched the victory in style as Chambers sprinted 71 yards for a touchdown after catching a short Jay Fiedler pass on third down.
It was by far the Dolphins' best performance of the season. They not only easily surpassed their highest scoring total of the season (13 points), they also played a turnover-free game for the first time in 2004.
The Dolphins shockingly were in control pretty much the whole game, taking the lead on Sammy Morris' 8-yard touchdown run one play after Booker hit Chambers with a 48-yard pass.
It was the first time all season the Dolphins had scored in the first quarter.
After St. Louis tied the game on Marc Bulger's 15-yard touchdown run in the second quarter, the Dolphins regained the lead on another big play, Fiedler's 42-yard pass to Randy McMichael on third-and-28.
The play came after the Rams accepted a holding penalty on the Dolphins after an incomplete pass that would have left the Dolphins in a fourth-and-18 and a 50-yard field goal attempt.
The Dolphins increased the lead to 21-7 on the third play of the fourth quarter when Travis Minor sprinted outside for a 13-yard touchdown.
The margin improved to 24-7 on a Matt Bryant field goal before the Rams scored late to make it 24-14 on a 15-yard touchdown pass to Shaun McDonald.
Chambers then slammed the door with his long touchdown, and the Rams' final drive ended when Zach Thomas sacked Bulger on fourth down.
It was a great way for the Dolphins to finally get in the win column.