The Dolphins were in total control after a strong first half but kind of let Tennessee back in the game after a 55-yard touchdown pass from Billy Volek, in for an injured Steve McNair, to Drew Bennett.
But the Dolphins defense shut the door on the Titans after that, never allowing them past their own 34-yard line on their last three drives.
The Dolphins took charge in the second quarter when Gus Frerotte hit Chambers for touchdown passes of 11 and 7 yards.
The 7-yarder, with 27 seconds left in the first half, saw Chambers grab the ball in the back of the end zone and then manage to get his feet in bounds.
The defense had one of its best performances of the season other than the long pass to Bennett.
Tennessee's first-half field goal was set up by a Dolphins turnover when Frerotte's attempted pitch to Williams hit fullback Darian Barnes in motion and the Titans recovered at the 10-yard line.
The Dolphins held Tennessee to 4 yards on three plays, forcing the field goal.
The victory ensures the Dolphins of at least a .500 season, which has to be considered quite an accomplishment in Nick Saban's first season.