The amazing thing about that game is that Chambers could have had even bigger numbers had he not dropped a couple of balls in the first half.
As it was, it was a tremendous performance, one that set franchise records for receptions and yards, and was good enough to earn Chambers AFC Offensive Player of the Week honors.
Chambers understands what he did last year against the Bills won't mean much on Sunday, but he certainly won't be lacking for confidence against the Buffalo secondary.
"I'm confident anyway, but it's good," Chambers said. "I'm sure they'll be licking their chops a little bit more. I know a couple of guys, Nate (Clements) and a couple of guys, I saw them over the summer. I didn't say nothing. They kind of knew what was going on. It will be good to get back out there, but I don't expect us to be down by three touchdowns in the fourth this time."
Of course, Chambers was referring to the 23-3 deficit the Dolphins overcame last December.
One way to avoid getting behind against Buffalo would be to get Chambers involved early on, something that didn't happen against Pittsburgh in this year's opener.
Chambers did drop a catchable pass in the end zone on a first-and-goal late in the first half, but overall his opportunities were very limited early on, in part because of pressure on Daunte Culpepper, in part because of good coverage by Steelers cornerback Ike Taylor.
But the Dolphins really don't want anything to keep them from getting Chambers involved early this time around.
""I definitely want to get the ball into our playmakers' hands," Culpepper said. "Chris is definitely a playmaker. You want to get it to him and get him into a rhythm early. That is our thinking, hopefully we can go out and execute the game plan and do that and take the proper steps to do that."
The Buffalo secondary will come to Miami short-handed, with former Dolphins safety Troy Vincent on injured reserve and safety Matt Bowen questionable because of a shin injury.
That means there should be plenty of playing time for rookie first-round pick Donte Whitner and also perhaps fellow rookie safeties Ko Simpson and Ashton Youboty.
But Chambers should count on seeing plenty of Clements, who guy who has been a Dolphins killer over the years.
That battle could wind up playing a part in determining the outcome. It's foolish to expect Chambers to come close to the numbers he put up last December, but he and the Dolphins certainly expect a bigger performance than in the opener.
And after last December, he's got every right to expect it.