Of course, at that point the score was 16-0 and the Bills were in a prevent defense.
The two-point conversion failed when Culpepper threw behind Chambers in the corner of the end zone and an onside kick was recovered by Buffalo, a fitting end to the disappointing day.
The Dolphins wound up outgaining Buffalo 282-171, but it was the Bills who got the big plays, namely a punt block and a 50-yard pass-interference penalty on Will Allen that set up their only touchdown.
Culpepper wound up getting sacked seven times and threw a costly interception late in the first half.
Buffalo took a 3-0 lead on a 33-yard field goal after a drive where all 49 yards were gained on the ground.
The Dolphins had a chance to tie the score early in the second quarter, but Olindo Mare's field goal attempt from 55 yards out missed wide right, which is a shame because the kick had plenty of distance.
The Dolphins had a chance to take the lead -- or at least tie the score -- late in the first half when they drove to a first-and-10 from the Bills 14-yard line, but on second down a scrambling Culpepper threw into triple coverage and the pass was intercepted by linebacker Angelo Crowell.
Buffalo scored the only touchdown of the game on its first drive of the second half when Losman connected with Josh Reed on a 4-yard pass, one play after the pass-interference call on Allen.
The Bills tacked on two field goals after two, the second coming after Coy Wire blocked a Donnie Jones punt to give Buffalo the ball at the Miami 17.
In the meantime, the Dolphins failed to get a first down on their first four possessions of the second half.
By the time they finally got something going offensively, it was way too little, way too late.