More importantly, it will be Edwards' first game since January of 1999.
"I do expect to be a little nervous once I first get out there," Edwards said on Wednesday afternoon. "But right now I don't feel it, but I know when I step on the field the first time the butterflies are going to set in."
By now, Edwards' story is pretty well known, how he tore up his right knee on the beaches of Hawaii in an all-star flag football game following his rookie season and how he has worked to complete what would be a miraculous comeback.
For Edwards, it's just about playing football again.
"I'm not really trying to prove anything," he said. "I just want to get out there and have fun and enjoy myself, and do things right and try to make this ballclub."
Edwards has been impressive enough in training camp to lead everyone to believe he will make the Dolphins roster, but the question is whether he can withstand the rigors of a full season.
The first test will be Thursday night. There has been no indication exactly how much playing time Edwards will get, but he is expected to come in sometime after Ricky Williams is pulled out of the game.
When asked how much playing time he was expecting, Edwards replied: "I don't know. That's up to the coaches. But I'll definitely be suited up and ready to go."