But the Colts still have Peyton Manning, Edgerrin James and Marvin Harrison. And that's enough to cause any defense some sleepless nights.
"It's always tough when you play Peyton because he's the smartest quarterback out there," said Zach Thomas, whom Manning called the smartest middle linebacker in the league. "He's always going to put up point. We have to try to not give up too many big plays and go from there. We can't get rattled because he's going to move the ball. They have one of the best offenses in the league.
"With Peyton, Edgerrin and Marvin all together, they've got the top players in the league."
The Dolphins have had pretty good success against the Colts in the past two years, holding them to 14, 20, 17, 24 and 6 points in five meetings.
But that doesn't make the challenge any less imposing, particularly now that the Colts have added wide receiver Qadry Ismail to their arsenal.
"They can score at any time from any spot on the field," said Coach Dave Wannstedt. "That's what you have to remind yourself every time you line up against these guys."