"It's nice," Williams said of facing his hometown team. "I grew up a Chargers fan. I was in high school when Junior Seau started with them. It's going to play against them.
"We played them there when I was with New Orleans. That was a lot of fun, too. So I'm looking forward to it."
Williams, who said his favorite Chargers player when he was growing up was running back Lionel "Little Train" James, will be looking for a bigger day on offense in his second meeting against San Diego.
Back in the 2000 season, Williams was held to 50 yards on 24 carries by the Chargers, although the Saints did rally for a 28-27 victory.
Williams, who is third in the AFC in rushing, will be looking to make up some ground on the NFL's rushing leader, the Chargers' LaDainian Tomlinson.
It's a matchup Williams also is looking forward to.
"It's always a challenge to go up against a top running back," he said. "A lot of times, although I don't play against them, you're measure against those kinds of guys in a big game like this.
"With two good run defenses, it is going to be a great game to watch to see who gets on track and who has a better game."