That kept the Dolphins' 17-10 lead and slowed the San Diego momentum.
San Diego got the ball back twice after that but couldn't advance past the Dolphins 46-yard line.
The last defensive play for the Dolphins was a Yeremiah Bell tipped pass on third-and-7, which forced the Chargers to punt.
The Dolphins got the ball back at their 15-yard line and proceeded to convert a third-and-2 (11-yard run by Ronnie Brown), a third-and-4 (14-yard completion from Chad Pennington to Ted Ginn Jr.), a third-and-1 (Brown 1-yard run) and finally a third-and-2 (Brown 5-yard run).
Brown had another big game for the Dolphins, rushing for 125 yards and a second-quarter touchdown that gave the Dolphins a 17-3 halftime lead.
The Dolphins were in total command halfway through the third quarter, leading 17-3 and lining up for a 42-yard field goal attempt.
But Dan Carpenter hooked the attempt wide left, and things started unraveling a little bit.
A 6-yard completion to Chambers, who sustained a leg injury on the play and had to be carted off the field, gave the Chargers their fourth-and-goal opportunity.
The Dolphins converted on their first-and-goal opportunity late in the first half to go into the locker room with their 17-3 lead, with Brown scoring on a 5-yard run.
On the other side, the Dolphins totally handled Tomlinson, holding him to 35 yards on 12 carries.
After the teams traded field goals on each of their first possessions, the Dolphins took the lead in the second quarter on a 17-yard pass from Pennington to former Charger Greg Camarillo.
It was a big victory for the Dolphins, who now stand 2-2 heading into next Sunday's game at Houston.