Holmes won't be a factor because he's not playing Saturday when the Chiefs travel to Oakland. As for Tomlinson, his Chargers face Seattle on Sunday afternoon.
Barring a disaster, it appears history will be made one way or another.
The Dolphins have never had a player lead the league in rushing. Larry Csonka had the best finish ever, coming in third in 1971.
As for sacks, the closest a Dolphins player has come to leading the league was in 2000 when Trace Armstrong finished with 16, half a sack behind New Orleans' La'Roi Glover.
Keep in mind, though, that sacks became an official NFL stat only in 1982.