The Jaguars know they're not going to rush for 375 yards against the Colts the way they did in the last game, but they still want to control the game to keep Peyton Manning off the field. They don't want to let Manning get into a shootout with David Garrard.
Jaguars CB Rashean Mathis vs. Colts WR Marvin Harrison. This is a critical matchup pitting one of the game's best receivers against a young cornerback who made the Pro Bowl last year. Harrison also will face Brian Williams, the corner on the other side because the Jaguars don't flip their corners.
Colts front seven and safety Bob Sanders vs. the Jaguars' running game. The Colts won the Super Bowl with the worst rushing defense in the league last year and they gave up 375 rushing yards to the Jaguars when Sanders didn't play. This year, the Colts are 13th in rush defense so they figure to do much better this time.