Favre was 23 of 33 with two touchdowns and two interceptions as the Packers improved to 4-6 and started a six-game winning streak that would bring them within a game of making the playoffs.
Favre played through a first-degree separation of his left shoulder that occurred when Philadelphia defensive end Reggie White delivered a brutal hit on his second pass of the game.
No one knew it at the time but White's hellacious hit would change the course of Packer history.
"One game in the '92 season made a big impression on me – the November 15 game against the Green Bay Packers at Milwaukee County Stadium," White wrote in his 1996 autobiography In the Trenches. "In fact, it would be fair to say that something happened in that game that changed the course of my career: I ran full tilt into a twenty-three old country boy named Brett Favre."
As he would do so many times in his career, Favre would not succumb to the pain.
"Packers coach Mike Holmgren wanted to take him out of the game, but Brett refused to leave," White wrote. "So the team doctor shot him with painkiller and sent him back in."
Three plays later, Favre hooked up with Sterling Sharpe on a 5-yard touchdown pass. The scoring toss was part of a first half in which Favre would throw 11 consecutive completions.
The performance made a lasting impact of White, who would sign with the Packers following the season. White's arrival in Green Bay hastened the arrival of the franchise's golden period of the mid-1990s.
"When I left the Philadelphia Eagles and began looking for a new home in which to play football, the vivid memory of Brett Favre straight through the punishment I put on him stuck in my mind," White wrote.
Favre and the Packers were able to build a 21-10 lead early in the fourth quarter behind a 1-yard TD run by Vince Workman and a 3-yard Favre-to-Darrell Thompson scoring pass.
Behind Randall Cunningham, the Eagles took the lead in the fourth quarter. Heath Sherman took a screen pass 75 yards for one TD and Herschel Walker scored from two yards out to give the Eagles a 24-21 lead with 5:45 left. Back-to-back pass interference penalties against Terrell Buckley and Roland Mitchell set up the Eagles' go-ahead score.
Seconds later, Favre threw an interception and the Eagles had the ball at the Green Bay 20 with about five minutes to play and in position to salt away the game.
Philadelphia, though, could not stand prosperity.
Sherman fumbled at the Packer 12 and LeRoy Butler recovered and returned the ball to the 27. Favre then moved the Packers into field goal range thanks to a 34-yard pass to Sharpe.
Chris Jacke's 31-yard field goal with 1:31 left tied the game at 24.
The Eagles started to drive for a game-winning field goal but Walker fumbled. Linebacker Johnny Holland recovered at the Eagle 23. After one play, Jacke kicked a 41-yard field goal as time expired to give the Packers an improbable victory.
"The ball hadn't been bouncing our way for a few years, and it finally did today," Holland said.