Running back James Starks (knee/ankle), receiver/kick returner Randall Cobb (groin) and receiver Greg Jennings (knee), who has missed the last two games, were ruled out for Sunday's regular-season finale. Meanwhile, coach Mike McCarthy would not say Friday whether quarterback Aaron Rodgers would join them on the sideline.
"The most important thing with Aaron is he's ready to play," McCarthy said. "It's important for the quarterbacks, we repped all three of them this week. So I'd like to see all three of them play in the game, is the initial plan as we started the week."
Rodgers didn't shed any light on whether he would play.
"I'm going to leave it up to Mike," he said.
The Packers also listed right tackle Bryan Bulaga (knee) as doubtful. So, whoever lines up at quarterback will be without two receivers, the No. 1 rusher and most likely the right tackle.
McCarthy has been coy this week about his approach to Sunday's game after the Packers (14-1) clinched the No. 1 seed and homefield advantage throughout the NFC playoffs.
While the playoffs-bound Lions (10-5) can gain the No. 5 seed in the NFC bracket by winning at Green Bay for the first time since 1991, the Packers don't have anything riding on the final score against their longtime rivals.
"It ain't the end of the world. We've still got them playoffs," Green Bay tight end Jermichael Finley said.
The Packers will have a first-round bye and won't play again until the Jan. 14-15 weekend.
McCarthy shrugged off the suggestion that a loss would hurt his team's momentum.
"I don't ever worry about the outcome of the game," he said. "I'm a firm believer in trusting the process. I truly believe we're going to win this football game. So, I'm more concerned with the process leading up to this game, and I'll be just as much concerned as the process leading up to our next competition.
"Games are won, in my opinion, throughout the week. We fully expect to win this game."
The Packers would be counting on a combination of Matt Flynn and Graham Harrell to lead the league's No. 1-scoring offense if Rodgers doesn't play for only the second time in his four seasons as the starter.
Flynn, a fourth-year player, made his only pro start Dec. 19, 2010, with Rodgers out because of a concussion. Flynn played well in the prime-time game on the road against the heavily favored New England Patriots, who hung on for a 31-27 win.
"I want to see Matt Flynn play like he did in New England, but take it a step further — win the game," McCarthy said.
Harrell could make debut
Harrell is anxious to get his first regular-season action since he signed with the Packers as a free agent in 2010.
"I'd love to get in, but we're going out to win," Harrell said.
And Harrell wouldn't be surprised if Flynn, not Rodgers, makes the start Sunday.
"It'll be interesting," Harrell said. "I don't think you can go wrong either way. Aaron, he's been healthy almost his whole career. He's a smart player, and he obviously helps us win,. So letting him get some action would be good for us, but if they decide to rest him, it obviously makes a ton of sense as well."
Packers injury report
Out — WR Randall Cobb (groin); WR Greg Jennings (knee); RB James Starks (knee/ankle). Doubtful: T Bryan Bulaga (knee). Questionable: LB Clay Matthews (ankle); CB Charles Woodson (knee). Probable: T Chad Clifton (hamstring/back); TE Jermichael Finley (knee); DE Ryan Pickett (concussion). "I definitely want to play," Pickett said. "I've been practicing like I'm playing. So, I'm pretty sure I'm playing. I'm ready to play."
Lions injury report
Doubtful: CB Aaron Berry (shoulder); S Louis Delmas (knee). Questionable: DT Nick Fairley (foot); CB Chris Houston (hand/knee); S Amari Spievey (knee); DT Corey Williams (hip); DE Willie Young (ankle). Probable: DE Cliff Avril (back); WR Calvin Johnson (Achilles); RB Kevin Smith (ankle); S John Wendling (illness).
Johnson was limited on Friday after missing the first two days.
— During the bye week, McCarthy said he'd hold typical practices on Wednesday and Thursday but wasn't sure if he'd give the players Friday-Saturday-Sunday off or just the weekend. If he chooses, McCarthy can put his players in pads for one practice, per the collective bargaining agreement. That's typically on Thursday.
— Pickett said the Packers don't like the Lions and that this is a significant game, regardless of who plays in it. "To go 15-1, that would be an unbelievable season. Definitely want to beat Detroit, don't care for Detroit that much. There's going to be a lot of trash talking and things like that. We've got an opportunity to sweep the division, so that would be big for us."
— For all the yards the Packers have allowed, only one thing matter, and that's winning the game, defensive coordinator Dom Capers said. To that end, Capers' unit has mostly held up its end of the bargain, with a No. 2 ranking in takeaways and a No. 12 ranking in points allowed.
— The Lions worked outside on Friday. "Honestly, it had nothing to do with the weather as much as it is the field conditions," Lions coach Jim Schwartz said. "You know, we saw a lot of players slipping around when Chicago played up there last week and wanted to go out and work that kind of timing and things like that, but the temperature was really irrelevant."
— In 2012, the Packers will have their usual home-and-away games against the NFC North,
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