To do so, it will be up to the backups who are replacing several key players.
McCarthy listed quarterback Aaron Rodgers, receivers Randall Cobb and Greg Jennings, running back James Starks, right tackle Bryan Bulaga, cornerback Charles Woodson and linebacker Clay Matthews as his seven inactives.
With Rodgers out, it ensures that he will set the NFL record for best single-season passer rating. He finishes at 122.5, just ahead of Peyton Manning's 121.1 in 2004.
The Packers will start Chad Clifton at left tackle and Marshall Newhouse at right tackle. Jordy Nelson, Donald Driver and James Jones are the only three receivers active, and Ryan Grant, Brandon Saine and John Kuhn will carry the load in the backfield.
On defense, Sam Shields jumps into the starting lineup, with Jarrett Bush presumably being the third cornerback. At outside linebacker, Brad Jones is starting for Matthews and Frank Zombo will get the call ahead of Erik Walden, who had started the previous 15 games.
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Bill Huber is publisher of Packer Report magazine and PackerReport.com and has written for Packer Report since 1997. E-mail him at firstname.lastname@example.org, or leave him a question in Packer Report's subscribers-only Packers Pro Club forum. Find Bill on Twitter at twitter.com/PackerReport.