Green Bay (1-1)went up 14-0 on Favre's 5-yard shovel pass to Tony Fisher on third-and-goal late in the first quarter.
The Lions'(1-1) production was limited to Jason Hanson's 22- and 52-yard field goals in the first half.
Green Bay's Ryan Longwell also connected on a 26-yard field goal.
The Packers led 17-6 at halftime. Favre closed the half with an interception - which led to a Lions' field goal, and Detroit's Joey Harrington opened the second half with an interception snagged by Mike McKenzie. Green Bay couldn't capitalize on that one, but rookie Nick Barnett gave them another chance minutes later. The linebacker posted his first career interception with about 12 minutes to go in the third quarter.
Barnett also led the Packers in tackles on the afternoon.
This time, the Packers took full advantage. On the ensuing series, Favre hit Ferguson with a touchdown laser to put the Packers up 24-6 with 10:18 to go in the third. Ferguson had a stellar day, especially considering he wasn't even expected to play. He aggravated his right ankle injury in the fourth quarter, but lobbied for his eventual return and came back in the final five minutes.
Cornerback Al Harris came up with the Packers' third interception with about 10 minutes left. He took this one in himself, 59 yards into the end zone for a convincing 31-6 Green Bay lead.
Favre finished with numbers that looked a lot better than last week. He had two touchdowns and one interception. He didn't waste any time getting reacquainted with his old friend Antonio Freeman, connecting three times including once for a 13-yard first down play in the first half.