The then 22-year-old QB had played briefly in the previous week's loss to Tampa Bay, but hadn't fared well.
Nobody could have predicted that the two touchdown passes he threw that afternoon would be the first of a career total that now stands at 348 - 381 including postseason - and counting.
The Cincinnati game also marked the first of Favre's long list of comebacks. The Packers were trailing 17-3 entering the fourth quarter, putting them on the brink of falling to 0-3.
Favre's first career TD pass came on a five-yard toss to Sterling Sharpe with 4:11 remaining in the fourth quarter. The score capped an 88-yard drive and pulled the Packers to within 20-17.
The Bengals raised the stakes with a field goal. Robert Brooks didn't help matters when he inadvertently stepped out of bounds on the 8 yard line on his return of the Bengals' final kickoff. That meant the Packers couldn't settle for a field goal and had only one minute and no times outs for the newcomer to direct a 92-yard touchdown drive.
Favre didn't need the time outs or even the entire 1:07 to get the job done. On the second play of the drive Favre hit Shrpe again with a 42-yard strike to the Cincinnati 46. Two plays later, Favre finished off one of the most memorable comebacks in Lambeau Field history. Favre connected with Kitrick Taylor for a 35-yard touchdown pass down the right sideline. Chris Jacke's extra point gave Green Bay the winning margin.
Favre's line read 22-of-39 for 289 yards with two touchdowns. He had absorbed five sacks but never surrendered the ball.
The win was the first of the season for the Packers under their new coach Mike Holmgren. With Favre at the helm (including the Cincy game) Green Bay went 9-5 after a shaky start for their first winning record in a full season since 1978.