Favre completed 33 of 50 passes for 383 yards, with one touchdown and two interceptions against the Texans. He led the Packers from a 10-point fourth-quarter deficit for his 32nd comeback victory in his career.
Donald Driver returned to his hometown for the first time as a pro, catching 10 passes for 148 yards, including a 24-yard touchdown catch that closed the Packers to 13-10 in the fourth quarter. Javon Walker added nine receptions for 88 yards.
Green Bay forced the Texans to punt six times on six, second-half possessions. Texans quarterback David Carr passed for 164 yards in the game, but for just 29 in the second half. The Texans (4-6) were ranked ninth in total offense in the National Football League entering the game, but were held to no first downs in the fourth quarter.
Defensive end Kabeer Gbaja-Biamila recorded two sacks for the second consecutive week to lead Green Bay's defense.
The Packers finished with 473 total yards of offense, but were penalized 10 times for 90 yards in the game.
"We had to work for it," said Packers coach and general manager Mike Sherman. "It wasn't handed to us, that's for sure. We knew coming in that we were going to see the very best they had to offer, but we had to respond. ... The injuries kind of threw us into a tizzy a little bit because we had guys in and out of the ballgame. With the running back situation, we were down to one tailback and no fullbacks at one point.
"I thought the guys came out with a purpose in the second half. I can't say enough about the way our defense kept us in the ballgame, so the offense gets a wake-up call and finds the end zone, and our kicker putting it through for another game-winning field goal. But our quarterback is the guy who kept us in the game, making plays with his feet and his arm and his head."
Texans, playing for the first time before a national television audience since their opening game as a franchise in 2002, lost their third straight game. The Texans were out-scored by opponents 80-27 in previous two games.
Texans kicker Kris Brown made a 46-yard field goal and followed with a 40-yarder just before halftime to give Houston a 13-3 lead.
Longwell gave the Packers a 3-0 lead by making a 23-yard field goal with 9:21 left in the first half. Favre's 15-yard completion to Javon Walker, followed by a 50-yard bomb to Driver put the Packers deep in Houston's territory.
The Packers drove 47 yards on 12 plays and used up the first 6:11 of the game, but Longwell's 49-yard field goal attempt was wide right. Brown also was wide right from 40 yards out after the Texans drove to Green Bay's 23 on their first series of the game.