The former Green Bay Packers wide receiver has been the Chargers' wide receivers coach for four seasons. Lofton said he couldn't comment because of head coach Marty Schottenheimer's rule barring assistants from being interviewed by the media.
San Diego State fired Tom Craft on this month after he went 19-29 in four seasons, including 5-7 this year. San Diego State hasn't had a winning season since 1998, when it played in the Las Vegas Bowl. The Aztecs have played in only two bowls the last 15 years.
SDSU athletic director Jeff Schemmel hopes to fill the job by Christmas.
Lofton was interested in the job at his alma mater, Stanford, when it opened last year, but the job went to Walt Harris. Lofton has never been a head coach.
During his 16-year NFL career, Lofton caught 764 passes for 14,004 yards and 75 touchdowns, becoming the first NFL player to pass the 14,000-yard mark. He played for the Packers from 1978-86 when he had 530 catches for a team record 9,656 yards.
Lofton played in three Super Bowls with Buffalo, was named All-Pro four times and was an eight-time Pro Bowler. He retired following the 1993 season and was inducted into the Hall of Fame in 2003.