Favre, who is expected to make his 250th consecutive start despite left shoulder and right elbow injuries, isn't likely to shy away from challenging Asomugha. His history suggests he'll trust his receivers and take his chances.
It was that way the last time Favre faced the Raiders on Dec. 22, 2003, as he strafed Oakland for 399 yards, four touchdowns and no interceptions in a 41-7 Green Bay win.
The game was viewed by a national television audience on Monday Night Football and played the day after Favre's father died suddenly of a heart attack.
As much as the Raiders saluted Favre that night, they also were embarrassed on a national stage.
"This is what we've all been waiting for," Asomugha said. "It's definitely what I've waited for. The last time we played them everyone knows what happened. It was a tough game, hearing what people were saying about us. I was just a rookie and didn't play that much, but enough for him to get me a couple of times.
"I know he's going to throw all over the field. He's not going to be like everyone else we've played and choose one side."
Asomugha played three seasons and was in 49 games before getting his first interception in the third game a year ago. He got two against Cleveland that day and finished with eight, the top defender on a defense ranked No. 1 in the NFL in terms of fewest passing yards allowed.
With a newfound reputation as one of the NFL's top young corners, Asomugha has a single interception this season and has rarely been tested. He was warned of the possibility in the offseason by Charles Woodson, the former Raider who got the same treatment in Oakland and now plays for Green Bay.
Asomugha can void his contract following the season, and unless the Raiders manage to lock him up with a long-term deal, he could be slapped with the franchise designation as Woodson was in two consecutive seasons.
In an open market, only New England's Asante Samuel would be in the same price range among corners. If all goes well against Favre and the Packers, it will only enhance Asomugha's value.
"You do get up for those types of games, especially (Favre)," Asomugha said. "With the legendary type of players, you're definitely going to have some opportunities."