All four are at least touchdown favorites entering the week, and certainly will be expected to advance to the conference championships. But who might be the most vulnerable to an upset?
Jacksonville is arguably the most dangerous team coming out of wild-card weekend, and its running game can help dominate time of possession. But the Jaguars are unlikely to upend New England with a secondary that has little hope of keeping the Patriots from routinely finishing drives in the end zone.
Indianapolis might have benefitted more than any of the four from the bye week. The Colts have been beat up most of the season, but could get wide receiver Marvin Harrison and a few other key starters back. And with San Diego struggling to put together four strong quarters in most games, the Chargers aren't a strong upset threat.
Green Bay faces a Seattle team that doesn't play well on the road. Plus the Seahawks' pass-heavy offense could take a hit with quarterback Matt Hasselbeck dealing with a sprained wrist on his throwing hand.
That brings us to Dallas. The Cowboys have already beaten the Giants twice by double digits this season. But that was back when Dallas was still playing explosive football on a weekly basis. It was also when wide receiver Terrell Owens was playing at full strength.
It doesn't help that offensive line coach Tony Sparano and offensive coordinator Jason Garrett spent the bye week on a whirlwind tour, both interviewing for the head coaching vacancies in Atlanta, Miami and Baltimore.
The Giants have probably played the best two games of the season the past two weeks, and their pass rush gives them a chance to produce the turnovers New York must get to have a chance.
"It's really a little too early to talk about Dallas," said Giants coach Tom Coughlin. "Obviously, we know them well, and they know us well, and sometimes I think that makes it easier but sometimes it seems more difficult to play a team for the third time in the same season."